If you set both reddit.com and redditstatic.com to TRUSTED Reddit should mostly work: as far as I can tell the only problem is SVG images (like the reddit logo) being rendered as CSS garbage because Safe mode additionally flips the global svg.disabled preference to true, which is out of NoScript’s scope.
There’s actually been some discussion of rather making SVG click to play / controlled by NoScript (e.g. Make SVG click-to-play and support fallback (#20314) · Issues · The Tor Project / Applications / Tor Browser · GitLab ), maybe it’s time to re-prioritize this.